Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study.

@article{Gouw2013IntensityOF,
  title={Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study.},
  author={S C Gouw and H M van den Berg and Kathelijn Fischer and Guenter Auerswald and Manuel D Carcao and Elizabeth A Chalmers and H{\'e}rv{\`e} Chambost and Karin Kurnik and Ri J Liesner and Pia Petrini and Helen Platokouki and Carmen Altisent and Johannes Oldenburg and Beatrice Nolan and Rosario P{\'e}rez Garrido and Maria Elisa Mancuso and Anne Rafowicz and Mike Williams and Niels Clausen and Rutger A Middelburg and Rolf C R Ljung and Johanna G van der Bom},
  journal={Blood},
  year={2013},
  volume={121 20},
  pages={4046-55}
}
The objective of this study was to examine the association of the intensity of treatment, ranging from high-dose intensive factor VIII (FVIII) treatment to prophylactic treatment, with the inhibitor incidence among previously untreated patients with severe hemophilia A. This cohort study aimed to include consecutive patients with a FVIII activity < 0.01 IU/mL, born between 2000 and 2010, and observed during their first 75 FVIII exposure days. Intensive FVIII treatment of hemorrhages or surgery… CONTINUE READING