Intensity-modulated proton therapy further reduces normal tissue exposure during definitive therapy for locally advanced distal esophageal tumors: a dosimetric study.

@article{Welsh2011IntensitymodulatedPT,
  title={Intensity-modulated proton therapy further reduces normal tissue exposure during definitive therapy for locally advanced distal esophageal tumors: a dosimetric study.},
  author={James William Welsh and D. Dom{\'i}nguez G{\'o}mez and Matthew B. Palmer and Beverly A Riley and Amin V Mayankkumar and Ritsuko Komaki and Lei-xi Dong and Xiarong Ronald Zhu and A. G. Likhacheva and Zhongxing Liao and Wayne Lewis Hofstetter and Jaffer A. Ajani and James D. Cox},
  journal={International journal of radiation oncology, biology, physics},
  year={2011},
  volume={81 5},
  pages={1336-42}
}
PURPOSE We have previously found that ≤ 75% of treatment failures after chemoradiotherapy for unresectable esophageal cancer appear within the gross tumor volume and that intensity-modulated (photon) radiotherapy (IMRT) might allow dose escalation to the tumor without increasing normal tissue toxicity. Proton therapy might allow additional dose escalation, with even lower normal tissue toxicity. In the present study, we compared the dosimetric parameters for photon IMRT with that for intensity… CONTINUE READING
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