Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy.

@article{Kemi2002IntensitycontrolledTR,
  title={Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy.},
  author={Ole Johan Kemi and Jan P{\aa}l Loennechen and Ulrik Wisl\off and \Oyvind Ellingsen},
  journal={Journal of applied physiology},
  year={2002},
  volume={93 4},
  pages={1301-9}
}
Whereas novel pathways of pathological heart enlargement have been unveiled by thoracic aorta constriction in genetically modified mice, the molecular mechanisms of adaptive cardiac hypertrophy remain virtually unexplored and call for an effective and well-characterized model of physiological mechanical loading. Experimental procedures of maximal oxygen consumption (VO(2 max)) and intensity-controlled treadmill running were established in 40 female and 36 male C57BL/6J mice. An inclination… CONTINUE READING