Intensified treatment with high dose Rifampicin and Levofloxacin compared to standard treatment for adult patients with Tuberculous Meningitis (TBM-IT): protocol for a randomized controlled trial

@inproceedings{Heemskerk2011IntensifiedTW,
  title={Intensified treatment with high dose Rifampicin and Levofloxacin compared to standard treatment for adult patients with Tuberculous Meningitis (TBM-IT): protocol for a randomized controlled trial},
  author={Dorothee Heemskerk and Jeremy N Day and Tran Thi Hong Chau and Nguyen Huy Dung and Nguyen Thi Bich Yen and Nguyen Duc Bang and Laura Merson and Piero Olliaro and Thomas Pouplin and Maxine Caws and Marcel Wolbers and Jeremy J. Farrar},
  booktitle={Trials},
  year={2011}
}
BACKGROUND Tuberculous meningitis is the most severe form of tuberculosis. Mortality for untreated tuberculous meningitis is 100%. Despite the introduction of antibiotic treatment for tuberculosis the mortality rate for tuberculous meningitis remains high; approximately 25% for HIV-negative and 67% for HIV positive patients with most deaths occurring within one month of starting therapy. The high mortality rate in tuberculous meningitis reflects the severity of the condition but also the poor… CONTINUE READING

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