Intensified CHOP regimen in aggressive lymphomas: maximal dose intensity and dose density of doxorubicin and cyclophosphamide.

@article{Balzarotti2002IntensifiedCR,
  title={Intensified CHOP regimen in aggressive lymphomas: maximal dose intensity and dose density of doxorubicin and cyclophosphamide.},
  author={Monica Balzarotti and Michele Spina and Barbara Sarina and Massimo Magagnoli and Luca Castagna and Isabella Milan and Cristina Ripa and Fiorenza Latteri and Daniele Bernardi and Alexia Bertuzzi and Anna Nozza and Massimo G Roncalli and Emanuela Morenghi and Umberto Tirelli and Armando Santoro},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2002},
  volume={13 9},
  pages={1341-6}
}
BACKGROUND Following our previous study of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) intensification in non-Hodgkin's lymphoma (NHL), in the present report we attempted to further increase dose intensity by shortening the between-course intervals with the support of growth factors. PATIENTS AND METHODS A total of 67 patients were enrolled. With a fixed dose of doxorubicin 75 mg/m(2), cyclophosphamide (CTX) was started at a dose of 1750 mg/m(2) and increased by 250 mg/m… CONTINUE READING