Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.

@article{Lapin1969IntensificationOT,
  title={Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.},
  author={I. Lapin and G. Oxenkrug},
  journal={Lancet},
  year={1969},
  volume={1 7586},
  pages={
          132-6
        }
}
  • I. Lapin, G. Oxenkrug
  • Published 1969
  • Medicine
  • Lancet
  • Abstract Psychic depression may result from deficiency of brain serotonin. It is suggested that in depression the production of tryptophane pyrrolase by the liver is stimulated by raised blood-corticosteroid levels. As a result the metabolism of tryptophane is shunted away from serotonin production, and towards kynurenine production. Blood-corticosteroid levels are raised in depression as a consequence of excitement of the amygdaloid complex, on which serotonin is normally an inhibitory… CONTINUE READING
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