• DOI:10.1016/S0140-6736(69)91140-4
Corpus ID: 34345004

Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.

@article{Lapin1969IntensificationOT,
  title={Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.},
  author={I. Lapin and G. Oxenkrug},
  journal={Lancet},
  year={1969},
  volume={1 7586},
  pages={
          132-6
        }
}

I. Lapin, G. Oxenkrug

Published 1969

Medicine

Lancet

Abstract Psychic depression may result from deficiency of brain serotonin. It is suggested that in depression the production of tryptophane pyrrolase by the liver is stimulated by raised blood-corticosteroid levels. As a result the metabolism of tryptophane is shunted away from serotonin production, and towards kynurenine production. Blood-corticosteroid levels are raised in depression as a consequence of excitement of the amygdaloid complex, on which serotonin is normally an inhibitory… CONTINUE READING

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