Intense exercise increases circulating endocannabinoid and BDNF levels in humans—Possible implications for reward and depression

  title={Intense exercise increases circulating endocannabinoid and BDNF levels in humans—Possible implications for reward and depression},
  author={E. Heyman and F. Gamelin and M. Goekint and F. Piscitelli and R. Meeusen},
  • E. Heyman, F. Gamelin, +2 authors R. Meeusen
  • Published 2012
  • Psychology, Medicine
  • Psychoneuroendocrinology
  • The endocannabinoid system is known to have positive effects on depression partly through its actions on neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF). As BDNF is also considered the major candidate molecule for exercise-induced brain plasticity, we hypothesized that the endocannabinoid system represents a crucial signaling system mediating the beneficial antidepressant effects of exercise. Here we investigated, in 11 healthy trained male cyclists, the effects of an intense… CONTINUE READING
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