Intense dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide compared with conventionally scheduled chemotherapy in high-risk primary breast cancer: mature results of an AGO phase III study.

@article{Moebus2010IntenseDS,
  title={Intense dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide compared with conventionally scheduled chemotherapy in high-risk primary breast cancer: mature results of an AGO phase III study.},
  author={Volker J Moebus and Christian Jackisch and Hans Joachim L{\"u}ck and Andreas du Bois and Christoph Thomssen and Christian Martin Kurbacher and Walther Christian Kuhn and Ulrike Nitz and Andreas Schneeweiss and Jens B. Huober and Nadia Harbeck and Gunter von Minckwitz and Ingo Bernard Runnebaum and Axel Hinke and Rolf Kreienberg and Gottfried E. Konecny and Michael Untch},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 17},
  pages={2874-80}
}
PURPOSE Patients with primary breast cancer who have extensive axillary lymph node involvement have a poor prognosis after conventional adjuvant therapy. We compared intense dose-dense (IDD) adjuvant chemotherapy with conventionally scheduled adjuvant chemotherapy in patients with high-risk primary breast cancer. PATIENTS AND METHODS In this randomized, phase III trial, a total of 1,284 eligible patients with four or more involved axillary lymph nodes were randomly assigned to receive IDD… CONTINUE READING

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