Intense and highly localized gene conversion activity in human meiotic crossover hot spots

@article{Jeffreys2004IntenseAH,
  title={Intense and highly localized gene conversion activity in human meiotic crossover hot spots},
  author={Alec John Jeffreys and Celia A May},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={151-156}
}
Meiotic gene conversion has an important role in allele diversification and in the homogenization of gene and other repeat DNA sequence families, sometimes with pathological consequences. But little is known about the dynamics of gene conversion in humans and its relationship to meiotic crossover. We therefore developed screening and selection methods to characterize sperm conversions in two meiotic crossover hot spots in the major histocompatibility complex (MHC) and one in the sex chromosomal… CONTINUE READING
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