Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

  title={Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait},
  author={Sanja Frani{\'c} and Maria M. Groen-Blokhuis and Conor V. Dolan and Mathijs V Kattenberg and Ren{\'e} Pool and Xiangjun Xiao and Paul Scheet and Erik A Ehli and Gareth Edward Davies and Sophie Van der Sluis and Abdel Abdellaoui and Narelle K. Hansell and Nicholas G. Martin and James J. Hudziak and Catherina E M van Beijsterveldt and Suzanne C Swagerman and Hilleke E. Hulshoff Pol and Eco J. C. de Geus and Meike Bartels and Hans Hilger Ropers and Jouke-Jan Hottenga and Dorret I. Boomsma},
  journal={European Journal of Human Genetics},
Multiple inquiries into the genetic etiology of human traits indicated an overlap between genes underlying monogenic disorders (eg, skeletal growth defects) and those affecting continuous variability of related quantitative traits (eg, height). Extending the idea of a shared genetic basis between a Mendelian disorder and a classic polygenic trait, we performed an association study to examine the effect of 43 genes implicated in autosomal recessive cognitive disorders on intelligence in an… CONTINUE READING
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