Integrins regulate centrosome integrity and astrocyte polarization following a wound.

@article{Peng2013IntegrinsRC,
  title={Integrins regulate centrosome integrity and astrocyte polarization following a wound.},
  author={Huashan Peng and Yen May Ong and Waris Ali Shah and P Chris Holland and Salvatore Carbonetto},
  journal={Developmental neurobiology},
  year={2013},
  volume={73 5},
  pages={333-53}
}
In response to a wound, astrocytes in culture extend microtubule-rich processes and polarize, orienting their centrosomes and Golgi apparatus woundside. β1 Integrin null astrocytes fail to extend processes toward the wound, and are disoriented, and often migrate away orthogonal, to the wound. The centrosome is unusually fragmented in β1 integrin null astrocytes. Expression of a β1 integrin cDNA in the null background yields cells with intact centrosomes that polarize and extend processes… CONTINUE READING
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