Integrins play a critical role in mechanical stress-induced p38 MAPK activation.

@article{Aikawa2002IntegrinsPA,
  title={Integrins play a critical role in mechanical stress-induced p38 MAPK activation.},
  author={Ryuichi Aikawa and Toshio Nagai and Sumiyo Kudoh and Yunzeng Zou and Mariko Tanaka and Masahito Tamura and Hiroshi Akazawa and Hiroyuki Takano and Ryozo Nagai and Issei Komuro},
  journal={Hypertension},
  year={2002},
  volume={39 2},
  pages={
          233-8
        }
}
Mechanical stress activates various hypertrophic responses, including activation of mitogen-activated protein kinases (MAPKs) in cardiac myocytes. Stretch activated extracellular signal-regulated kinases partly through secreted humoral growth factors, including angiotensin II, whereas stretch-induced activation of c-Jun NH(2)-terminal kinases and p38 MAPK was independent of angiotensin II. In this study, we examined the role of integrin signaling in stretch-induced activation of p38 MAPK in… CONTINUE READING

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