Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival.

@article{Moro1998IntegrinsIA,
  title={Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival.},
  author={Luigi Moro and Mascia Venturino and Chiarella Bozzo and Lorenzo Silengo and Fiorella Altruda and Laura Beguinot and Guido Tarone and Paola Defilippi},
  journal={The EMBO journal},
  year={1998},
  volume={17 22},
  pages={
          6622-32
        }
}
Adhesion of human primary skin fibroblasts and ECV304 endothelial cells to immobilized matrix proteins, beta1 or alphav integrin antibodies stimulates tyrosine phosphorylation of the epidermal growth factor (EGF) receptor. This tyrosine phosphorylation is transiently induced, reaching maximal levels 30 min after adhesion, and it occurs in the absence of receptor ligands. Similar results were observed with EGF receptor-transfected NIH-3T3 cells. Use of a kinase-negative EGF receptor mutant… CONTINUE READING

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