Integrins in regulation of tissue development and function.

  title={Integrins in regulation of tissue development and function.},
  author={Erik H. J. Danen and Arnoud Sonnenberg},
  journal={The Journal of pathology},
  volume={201 4},
Cell adhesion is indispensable for embryonic development and for proper tissue function. In metazoans, integrins are the major adhesion receptors that connect cells to components of the extracellular matrix. Integrins are implicated in assembly of extracellular matrices, cell adhesion and migration on extracellular matrices, and in vertebrates (in which the integrin family has expanded) they can also mediate cell-cell adhesion. Furthermore, integrin-mediated adhesion can modulate many different… CONTINUE READING

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