Integrins in prostate cancer progression.

  title={Integrins in prostate cancer progression.},
  author={Hira Lal Goel and Jing Li and Sophia Kogan and Lucia R. Languino},
  journal={Endocrine-related cancer},
  volume={15 3},
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets. 

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