Integrins in platelet activation.

@article{Nieswandt2009IntegrinsIP,
  title={Integrins in platelet activation.},
  author={Bernard Nieswandt and D{\'a}vid Varga-Szab{\'o} and Margitta Elvers},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2009},
  volume={7 Suppl 1},
  pages={
          206-9
        }
}
Heterodimeric receptors of the beta1 and beta3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation. This review summarizes recent advances in understanding the functional regulation and (patho-) physiological significance of individual platelet integrins with a special focus on… CONTINUE READING
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  • A Banno, GinsbergMH
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