Integrins in mechanotransduction.

  title={Integrins in mechanotransduction.},
  author={Tyler D Ross and Brian G Coon and Sanguk Yun and Nicolas Baeyens and Keiichiro Tanaka and Mingxing Ouyang and Martin A Schwartz},
  journal={Current opinion in cell biology},
  volume={25 5},
Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects… CONTINUE READING

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