Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected].

@article{Rosenow2008IntegrinsAA,
  title={Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected].},
  author={Felix Rosenow and Rainer Ossig and Dorit Thormeyer and Peter Gasmann and Kerstin Schl{\"u}ter and Georg Brunner and J{\"o}rg Haier and Johannes A Eble},
  journal={Neoplasia},
  year={2008},
  volume={10 2},
  pages={168-76}
}
Metastasis comprises several subsequent steps including local invasion and intravasation at the primary site, then their adhesion/arrest within the vessels of host organs followed by their extravasation and infiltration into the target organ stroma. In contrast to previous studies which have used aspartate-glycine-arginine (RGD) peptides and antibodies against integrins, we used rare collagen- and laminin-antagonizing integrin inhibitors from snake venoms to analyze the colonization of the… CONTINUE READING
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