Integrins and their ligands.

  title={Integrins and their ligands.},
  author={Arnoud Sonnenberg},
  journal={Current topics in microbiology and immunology},
Integrins are expressed on almost every cell type and are responsible for the linkage of the extracellular matrix with the cytoskeleton. In this review I have focused on the intra- and extracellular proteins that bind to integrins. Although many integrins bind to the same extracellular ligand, they mostly recognize different sites on these ligands. Some integrins interact with the same site but then there are requirements for different additional sequences to obtain high affinity. By modulating… CONTINUE READING

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