Integrins and cadherins as therapeutic targets in fibrosis

Abstract

Fibrosis is the excessive deposition of extracellular matrix proteins into tissues leading to scar formation, disruption of normal tissue architecture and organ failure. Despite the large clinical impact of fibrosis, treatment options are limited. Adhesion molecules, in particular αvβ6 and α3β1 integrins and cadherin-11, have been demonstrated to be… (More)
DOI: 10.3389/fphar.2014.00131

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