Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin

  title={Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin},
  author={Anthony Leyme and Arthur Marivin and Lorena Perez-Gutierrez and Lien T M Nguyen and Mikel Garcia-Marcos},
  booktitle={The Journal of cell biology},
Signal transduction via integrins and G protein-coupled receptors is critical to control cell behavior. These two receptor classes have been traditionally believed to trigger distinct and independent signaling cascades in response to extracellular cues. Here, we report a novel mechanism of integrin signaling that requires activation of the trimeric G protein Gαi by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known as Girdin), a metastasis-associated protein. We… CONTINUE READING
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