Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse

@inproceedings{Jankowska2018IntegrinsMT,
  title={Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse},
  author={Katarzyna Izabela Jankowska and Edward K. Williamson and Nathan H Roy and Daniel Blumenthal and Vidhi Chandra and Tobias Baumgart and Janis K Burkhardt},
  booktitle={Front. Immunol.},
  year={2018}
}
Full T cell activation requires coordination of signals from multiple receptor-ligand pairs that interact in parallel at a specialized cell-cell contact site termed the immunological synapse (IS). Signaling at the IS is intimately associated with actin dynamics; T cell receptor (TCR) engagement induces centripetal flow of the T cell actin network, which in turn enhances the function of ligand-bound integrins by promoting conformational change. Here, we have investigated the effects of integrin… CONTINUE READING
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