Integrins: sensors of extracellular matrix and modulators of cell function.

@article{Pozzi2003IntegrinsSO,
  title={Integrins: sensors of extracellular matrix and modulators of cell function.},
  author={Ambra Pozzi and Roy Zent},
  journal={Nephron. Experimental nephrology},
  year={2003},
  volume={94 3},
  pages={e77-84}
}
Integrins are a large family of transmembrane receptors for extracellular matrix (ECM) molecules. They play a critical role in organ morphogenesis, physiology and pathology, as they can modulate and control different cell functions, including adhesion, shape, polarity, growth, differentiation and motility. Integrins interact with ECM components via their extracellular domains, while their cytoplasmic domains play a pivotal role in mediating integrin-dependent cellular functions. The integrin… CONTINUE READING