Integrins: roles in cancer development and as treatment targets

@article{Jin2004IntegrinsRI,
  title={Integrins: roles in cancer development and as treatment targets},
  author={Hui Jin and Judith A. Varner},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={561 - 565}
}
The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (α5β1, αvβ3 and… CONTINUE READING
Highly Cited
This paper has 429 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 221 extracted citations

Tenascin-C and integrins in cancer

Cell adhesion & migration • 2015
View 14 Excerpts
Highly Influenced

430 Citations

02040'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 430 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Inhibition of endothelial cell survival and angiogenesis by protein kinase A.

The Journal of clinical investigation • 2002
View 11 Excerpts
Highly Influenced

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 2 Excerpts
Highly Influenced

Disruption of epithelial cell-matrix interactions induces apoptosis

The Journal of cell biology • 1994
View 2 Excerpts
Highly Influenced