Integrins: molecular determinants of glioma invasion.

  title={Integrins: molecular determinants of glioma invasion.},
  author={Giovanna M D'Abaco and Andrew H. Kaye},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  volume={14 11},
Gliomas, the most common form of brain tumour are characterised by a capacity to invade throughout normal brain tissue. This infiltrative nature is the hallmark of poor prognosis. A greater understanding of the molecular determinants that drive invasion may lead to improved therapy. Integrins are a large family of cell surface receptors that mediate interaction between a cell and the extracellular matrix. Integrins facilitate extracellular matrix dependent organization of the cytoskeleton and… CONTINUE READING