Integrins: masters and slaves of endocytic transport

  title={Integrins: masters and slaves of endocytic transport},
  author={Patrick T. Caswell and Suryakiran Vadrevu and Jim C. Norman},
  journal={Nature Reviews Molecular Cell Biology},
Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors… 

Regulation of integrins by conformation and traffic: it takes two to tango.

The endo-exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility.

Endocytic Trafficking of Integrins in Cell Migration

Integrins Control Vesicular Trafficking; New Tricks for Old Dogs

Integrin traffic – the update

The initial concept of integrin traffic as a means to translocate adhesion receptors within the cell has now been expanded with the growing appreciation that traffic is intimately linked to the cell signalling apparatus.

Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction

A new integrin trafficking pathway is suggested in which endocytosed integrins are transported from VAMP3-containing recycling endosomes to STX6-containing trans-Golgi network before being recycled to the plasma membrane.

β1A Integrin Is a Master Regulator of Invadosome Organization and Function

Use of patterned surfaces, reverse genetics, and time-controlled photoinactivation showed that β1 but not β3 integrins are required for invadosome formation, self-assembly, and stabilization into a

Extracellular matrix internalization links nutrient signalling to invasive migration

  • E. Rainero
  • Biology
    International journal of experimental pathology
  • 2018
This short review will highlight how extracellular protein (including ECM) endocytosis impinges on the activation of the mechanistic target of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth, which supports the intriguing hypothesis that ECM components may be considered as nutrient sources, primarily under soluble nutrient‐depleted conditions.

Mechanisms of integrin activation and trafficking.




Integrin Trafficking and the Control of Cell Migration

The findings of studies revealing the molecular mechanisms controlling integrin traffic are summarized, particularly those providing indications as to how these processes contribute to cell migration and tumour cell invasiveness.

Integrin traffic

Mechanistic insight is provided into how integrin traffic is regulated in cells by controlling small GTPases or stabilizing cytoskeletal tracks that are crucial for efficient traffic of integrins to the plasma membrane.

Oriented endocytic recycling of α5β1 in motile neutrophils

It is demonstrated that the endocytic recycling compartment reorients to retain its localization just behind the leading lamella as PMNs migrate, indicating that membrane recycling during neutrophil migration has directionality.

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins

In conclusion, overexpression of Rab21 fails to induce cell adhesion via an integrin point mutant deficient in Rab21 association, which provides mechanistic insight into how integrins are targeted to intracellular compartments and how their traffic regulatescell adhesion.

Integrin signaling revisited.

Integrin trafficking regulated by Rab21 is necessary for cytokinesis.