Integrins: masters and slaves of endocytic transport

@article{Caswell2009IntegrinsMA,
  title={Integrins: masters and slaves of endocytic transport},
  author={Patrick T. Caswell and Suryakiran Vadrevu and Jim C. Norman},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={843-853}
}
Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors… 

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  • Biology
    International journal of experimental pathology
  • 2018
This short review will highlight how extracellular protein (including ECM) endocytosis impinges on the activation of the mechanistic target of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth, which supports the intriguing hypothesis that ECM components may be considered as nutrient sources, primarily under soluble nutrient‐depleted conditions.

Mechanisms of integrin activation and trafficking.

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