Integrins, adhesion, and cardiac remodeling.

  title={Integrins, adhesion, and cardiac remodeling.},
  author={Willa A. Hsueh and Ronald E. Law and Young Soo Do},
  volume={31 1 Pt 2},
Integrins are heterodimeric cell surface receptors that mediate a cell's ability to perceive its environment, respond to changed in its environment, and alter its environment. When activated, these receptors form focal adhesions, which are areas of close attachment of the cells to extracellular matrix proteins in which colocalization of cytoskeletal proteins, intracellular signaling molecules, and growth factor receptors occurs. In cardiac fibroblasts, integrins mediate cell growth and adhesion… CONTINUE READING
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