Integrins, Oncogenes, and Anchorage Independence

@article{Schwartz1997IntegrinsOA,
  title={Integrins, Oncogenes, and Anchorage Independence },
  author={Martin A Schwartz},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={139},
  pages={575 - 578}
}
proteins, termed anchorage independence of growth, correlates closely with tumorigenicity in animal models (14). This property of cancer cells presumably reflects the tendency of tumor cells to survive and grow in inappropriate locations in vivo. Such incorrect localization, as occurs in invasion and metastasis, is the characteristic that distinguishes malignant from benign tumors (31). Great progress has been made in the last 20 years toward understanding how growth is controlled in normal… CONTINUE READING
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