Integrin tyrosine phosphorylation in platelet signaling.

  title={Integrin tyrosine phosphorylation in platelet signaling.},
  author={David R. Phillips and Kalli Srinivasa Nageswara Prasad and Jeanne M. Manganello and Ming Bao and Lisa Nannizzi-Alaimo},
  journal={Current opinion in cell biology},
  volume={13 5},
The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals. 

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