Integrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation and release in tumor.

@article{Huang2014IntegrintargetedZP,
  title={Integrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation and release in tumor.},
  author={Pingsheng Huang and Huijuan Song and Weiwei Wang and Yu Sun and Junhui Zhou and Xue Wang and Jianfeng Liu and Deling Kong and Anjie Dong},
  journal={Biomacromolecules},
  year={2014},
  volume={15 8},
  pages={3128-38}
}
Reasonably structural design of nanoparticles (NPs) to combine functions of prolonged systemic circulation, enhanced tumor targeting and specific intracellular drug release is crucial for antitumor drug delivery. Combining advantages of Arg-Gly-Asp (RGD) for active tumor targeting, zwitterionic polycarboxybetaine methacrylate (PCB) for prolonged systemic circulation, poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) for acid-triggered intracellular release, novel RGD-PCB-b-PDPA (RGD-PCD… CONTINUE READING

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