Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors.

@article{Pesonen2012IntegrinTO,
  title={Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors.},
  author={Sari Pesonen and Iulia Diaconu and Vincenzo Cerullo and Sophie Escutenaire and Mari Raki and Lotta Kangasniemi and Petri Nokisalmi and Gianpietro Dotti and Kilian Guse and Leena Laasonen and Kaarina Partanen and Eerika Karli and Elina Haavisto and Minna Oksanen and Aila Karioja-Kallio and P{\"a}ivi Hannuksela and Sirkka-Liisa Holm and Satu Kauppinen and Timo K Joensuu and Anna Kanerva and Akseli Hemminki},
  journal={International journal of cancer},
  year={2012},
  volume={130 8},
  pages={1937-47}
}
The safety of oncolytic viruses for treatment of cancer has been shown in clinical trials while antitumor efficacy has often remained modest. As expression of the coxsackie-adenovirus receptor may be variable in advanced tumors, we developed Ad5-D24-RGD, a p16/Rb pathway selective oncolytic adenovirus featuring RGD-4C modification of the fiber. This allows viral entry through alpha-v-beta integrins frequently highly expressed in advanced tumors. Advanced tumors are often immunosuppressive which… CONTINUE READING

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