Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.

@article{Sewald2008IntegrinSC,
  title={Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.},
  author={Xaver Sewald and Bettina Gebert-Vogl and Sandra Prassl and Iris Barwig and Evelyn Weiss and Monica V Fabbri and Radim Osicka and Matthias Schiemann and Dirk H Busch and Monika Semmrich and Bernhard Holzmann and Peter {\vS}ebo and Rainer Haas},
  journal={Cell host & microbe},
  year={2008},
  volume={3 1},
  pages={
          20-9
        }
}
Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. VacA has immunosuppressive effects, inhibiting interleukin-2 (IL-2) secretion by interference with the T cell receptor/IL-2 signaling pathway at the level of calcineurin, the Ca2+-calmodulin-dependent phosphatase. Here, we show that VacA efficiently enters activated, migrating primary human T lymphocytes by… CONTINUE READING
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