Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent

Abstract

Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, α1… (More)
DOI: 10.1007/s11010-008-9900-8

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