Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent


Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, α1… (More)
DOI: 10.1007/s11010-008-9900-8


6 Figures and Tables