Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans.

@article{Pinkse2006IntegrinSV,
  title={Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans.},
  author={Gabrielle G. M. Pinkse and Wendy P Bouwman and Reshma Jiawan-Lalai and Onno T. Terpstra and Jan Anthonie Bruijn and Emile de Heer},
  journal={Diabetes},
  year={2006},
  volume={55 2},
  pages={312-7}
}
Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet cells appears soon after islet isolation and primarily involves the beta-cell. The purpose of this study was to determine the effect of ligation to extracellular matrix (ECM) proteins on survival of the islets of Langerhans following islet isolation. Islets that had been cultured for 24 h on collagen type I showed an islet survival of 59… CONTINUE READING

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