Integrin regulation of cell signalling and motility.

@article{Juliano2004IntegrinRO,
  title={Integrin regulation of cell signalling and motility.},
  author={Rudolph L Juliano and Peter J. Reddig and Suresh K. Alahari and Matthew L. Edin and Alan K. Howe and Andrew E. Aplin},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt3},
  pages={
          443-6
        }
}
Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. Integrins and PAKs also play a role in the… 
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