Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

@article{HermanowskiVosatka1992IntegrinMF,
  title={Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins},
  author={Anne Hermanowski-Vosatka and Jos A. G. van Strijp and William J. Swiggard and Samuel D. Wright},
  journal={Cell},
  year={1992},
  volume={68},
  pages={341-352}
}
The avidity of integrin CR3 (also known as alpha M beta 2, Mac-1, Mo-1, and CD11b/CD18) may be reversibly altered without changes in the number of cell surface receptors. Here we describe a molecule termed integrin modulating factor (IMF-1), which controls CR3 avidity. Addition of IMF-1 to polymorphonuclear leukocytes (PMNs) or to purified CR3 causes enhanced binding of ligand. IMF-1 is not present in resting PMNs, but stimulation of cells results in a transient rise in IMF-1 content that… CONTINUE READING

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