Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.

@article{Nishimura2009IntegrinmediatedTG,
  title={Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.},
  author={Stephen L Nishimura},
  journal={The American journal of pathology},
  year={2009},
  volume={175 4},
  pages={1362-70}
}
A subset of integrins function as cell surface receptors for the profibrotic cytokine transforming growth factor-beta (TGF-beta). TGF-beta is expressed in an inactive or latent form, and activation of TGF-beta is a major mechanism that regulates TGF-beta function. Indeed, important TGF-beta activation mechanisms involve several of the TGF-beta binding integrins. Knockout mice suggest essential roles for integrin-mediated TGF-beta activation in vessel and craniofacial morphogenesis during… CONTINUE READING
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