Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells.

@article{Thinwa2014IntegrinmediatedFS,
  title={Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells.},
  author={Josephine Thinwa and J. Armando Segovia and Santanu Bose and Peter H Dube},
  journal={Journal of immunology},
  year={2014},
  volume={193 3},
  pages={1373-82}
}
How intestinal epithelial cells (IECs) recognize pathogens and activate inflammasomes at intestinal surfaces is poorly understood. We hypothesized that IECs use integrin receptors to recognize pathogens and initiate inflammation within the intestinal tract. We find that IECs infected with Yersinia enterocolitica, an enteric pathogen, use β1 integrins as pathogen recognition receptors detecting the bacterial adhesin invasin (Inv). The Inv-integrin interaction provides the first signal for NLRP3… CONTINUE READING

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