Integrin-mediated differentiation of a pancreatic carcinoma cell line is independent of FAK or MAPK activation levels.

@article{Stagge2001IntegrinmediatedDO,
  title={Integrin-mediated differentiation of a pancreatic carcinoma cell line is independent of FAK or MAPK activation levels.},
  author={Volker Stagge and Thomas Seufferlein and Daniel D{\"u}rschmied and Andr{\'e} Menke and Guido Adler and M. v. Barton J. W. Beil},
  journal={Pancreas},
  year={2001},
  volume={23 3},
  pages={236-45}
}
INTRODUCTION The extracellular matrix (ECM) plays a salient role for proliferation and differentiation of epithelial cells. It was demonstrated that cell-ECM interactions mediated through integrins control gene expression and the tissue phenotype even in malignant tumors. Alterations of the ECM are a key feature of ductal adenocarcinoma of the pancreas. AIMS To examine the role of integrins and related signaling events for differentiation. METHODOLOGY AND RESULTS We established an in vitro… CONTINUE READING