Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury.

@article{Cordes2006IntegrinmediatedCI,
  title={Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury.},
  author={Nils Cordes},
  journal={Cancer letters},
  year={2006},
  volume={242 1},
  pages={11-9}
}
Interactions of cells with their microenvironment modify the cellular sensitivity of normal and tumor cells for radiation- and drug-induced genotoxic injury. The preexistent or acquired cellular resistance against such agents aggravates anticancer therapies and, therefore, complicates the recovery of patients. Recently, integrin-mediated adhesion was shown to improve cell survival of both normal and cancer cells following DNA damage. Here, I will discuss the role of integrins and integrin… CONTINUE READING