Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

Abstract

The serine threonine kinase protein kinase B regulates cellular activities as diverse as glycogen metabolism and apoptosis. Full activation of protein kinase B requires 3-phosphoinositides and dual phosphorylation on threonine-308 and serine-473. CaM-K kinase and 3-phosphoinositide dependent-kinase-1 phosphorylate threonine-308. Integrin-linked kinase… (More)
DOI: 10.1038/sj.onc.1203258

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