Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.

@article{Assi2008IntegrinlinkedKR,
  title={Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.},
  author={Kiran Assi and Jillian Mills and David Owen and Cwm Ong and Ren{\'e} St -Arnaud and Shoukat Dedhar and Baljinder Salh},
  journal={Gut},
  year={2008},
  volume={57 7},
  pages={
          931-40
        }
}
BACKGROUND Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter is currently lacking. AIM The hypothesis that epithelial cell-specific deletion of ILK would impact on murine tumourigenesis was tested using a colitis-associated cancer model… CONTINUE READING

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