Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.

@article{Kiss2002IntegrinlinkedKP,
  title={Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.},
  author={Enik{\~o} Kiss and Andrea Mur{\'a}nyi and Csilla Csortos and P{\'a}l Gergely and Masaaki Ito and David J. Hartshorne and Ferenc Erdődi},
  journal={The Biochemical journal},
  year={2002},
  volume={365 Pt 1},
  pages={79-87}
}
The myosin phosphatase (MP) composed of the catalytic subunit of type 1 protein phosphatase and myosin phosphatase target subunit isoform 1 (MYPT1) was identified as the major serine/threonine phosphatase component in the platelet-cytoskeleton fraction. MYPT1 was phosphorylated by cytoskeletal kinase(s), but the identity of the kinase(s) and the effect of phosphorylation were not established. Incubation of platelet-cytoskeletal fraction with MgATP or MgATP[S] (magnesium adenosine 5'-[gamma-thio… CONTINUE READING
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Identification of the endogenous smooth muscle myosin phosphatase-associated kinase

  • A. nyi, A. V. Somlyo, D. J. Hartshorne, T. A. Haystead
  • Proc. Natl. Acad. Sci. U.S.A
  • 2001

Protein kinase C-catalyzed phosphorylation of an inhibitory

  • M. Nishikawa
  • 2001

Agonists trigger

  • T. Kitazawa, M. Eto, T. P. Woodsome, D. L. Brautigan
  • 2000

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