Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.

  title={Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.},
  author={Vasiliki Gkretsi and William C. Bowen and Yu Yang and Chuanyue Wu and George K Michalopoulos},
  journal={Biochemical and biophysical research communications},
  volume={353 3},
Hepatocytes have restricted proliferative capacity in culture and when cultured without matrix, lose the hepatocyte-specific gene expression and characteristic cellular micro-architecture. Overlay of matrix-preparations on de-differentiated hepatocytes restores differentiation. Integrin-linked kinase (ILK) is a cell-matrix-adhesion protein crucial in fundamental processes such as differentiation and survival. In this study, we investigated the role of ILK, and its binding partners PINCH, alpha… CONTINUE READING