Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cells.

@article{Joshi2007IntegrinlinkedKI,
  title={Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cells.},
  author={Manjunath B. Joshi and Danila Ivanov and Maria Philippova and P. Erne and Th{\'e}rese J. Resink},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 12},
  pages={3083-95}
}
Glycosylphosphatidylinositol-anchored T-cadherin (T-cad) influences several parameters of angiogenesis including endothelial cell (EC) differentiation, migration, proliferation, and survival. This presupposes signal transduction networking via mediatory regulators and molecular adaptors since T-cad lacks transmembrane and cytosolic domains. Here, using pharmacological inhibition of PI3K, adenoviral-mediated T-cad-overexpression, siRNA-mediated T-cad-depletion, and agonistic antibody-mediated… CONTINUE READING

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