Integrin-linked kinase – essential roles in physiology and cancer biology

@article{Mcdonald2008IntegrinlinkedK,
  title={Integrin-linked kinase – essential roles in physiology and cancer biology},
  author={P. Mcdonald and A. Fielding and S. Dedhar},
  journal={Journal of Cell Science},
  year={2008},
  volume={121},
  pages={3121 - 3132}
}
Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions and regulates many cellular processes, including growth, proliferation, survival, differentiation, migration, invasion and angiogenesis. The use of recently developed Cre-lox-driven recombination and RNA-interference technologies has enabled the evaluation of the physiological roles of ILK in several major organ systems. Significant developmental and tissue-homeostasis defects occur when the… Expand

Figures, Tables, and Topics from this paper

Integrin-linked kinase: Not so ‘pseudo’ after all
Integrin-linked kinase 1: role in hormonal cancer progression.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 132 REFERENCES
Integrin-Linked Kinase Regulates Endothelial Cell Survival and Vascular Development
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis
The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma
Integrin-linked kinase: a cancer therapeutic target unique among its ILK
Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.
Critical Role of Integrin-Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development
Mapping the integrin-linked kinase interactome using SILAC.
...
1
2
3
4
5
...