Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties.

  title={Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties.},
  author={N Yoganathan and Albert Y. Yee and Zhongjian Zhang and D-J. Leung and Jun Yan and Ladan Fazli and Dejan Koji{\'c} and Penelope C. Costello and Mogjan Jabali and Shoukat Dedhar and Jasbinder S. Sanghera},
  journal={Pharmacology & therapeutics},
  volume={93 2-3},
Integrin-linked kinase (ILK) is an ankyrin repeat-containing Ser/Thr kinase that interacts with the cytoplasmic domains of beta(1) and beta(3) integrins. ILK is widely expressed in tissues throughout the body, and, as might be expected, appears to mediate a diversity of functions relating to its role in coupling integrins and growth factor receptors to downstream signaling pathways. Through its downstream targets protein kinase B/Akt and glycogen synthase kinase-3beta, ILK appears to be… CONTINUE READING


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