Integrin ligands at a glance.


Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently linked, heterodimeric molecules containing an and a subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 subunit and 8 subunit genes, and to date 24 different combinations have been identified at the protein level. Although some subunits appear only in a single heterodimer, 12 integrins contain the 1 subunit, and five contain V.

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@article{Humphries2006IntegrinLA, title={Integrin ligands at a glance.}, author={Jonathan D Humphries and Adam Byron and Martin J Humphries}, journal={Journal of cell science}, year={2006}, volume={119 Pt 19}, pages={3901-3} }