Integrin inside-out signaling and the immunological synapse.

  title={Integrin inside-out signaling and the immunological synapse.},
  author={Timothy A Springer and Michael L. Dustin},
  journal={Current opinion in cell biology},
  volume={24 1},
Integrins dynamically equilibrate between three conformational states on cell surfaces. A bent conformation has a closed headpiece. Two extended conformations contain either a closed or an open headpiece. Headpiece opening involves hybrid domain swing-out and a 70 Å separation at the integrin knees, which is conveyed by allostery from the hybrid-proximal end of the βI domain to a 3 Å rearrangement of the ligand-binding site at the opposite end of the βI domain. Both bent-closed and extended… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 124 extracted citations


Publications referenced by this paper.
Showing 1-10 of 53 references

Structural basis for allostery in integrins and binding of fibrinogenmimetic therapeutics

  • T Xiao, J Takagi, J-h Wang, BS Coller, TA Springer
  • Nature
  • 2004
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…