Integrin inside-out signaling and the immunological synapse.

@article{Springer2012IntegrinIS,
  title={Integrin inside-out signaling and the immunological synapse.},
  author={Timothy A Springer and Michael L. Dustin},
  journal={Current opinion in cell biology},
  year={2012},
  volume={24 1},
  pages={107-15}
}
Integrins dynamically equilibrate between three conformational states on cell surfaces. A bent conformation has a closed headpiece. Two extended conformations contain either a closed or an open headpiece. Headpiece opening involves hybrid domain swing-out and a 70 Å separation at the integrin knees, which is conveyed by allostery from the hybrid-proximal end of the βI domain to a 3 Å rearrangement of the ligand-binding site at the opposite end of the βI domain. Both bent-closed and extended… CONTINUE READING

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Structural basis for allostery in integrins and binding of fibrinogenmimetic therapeutics

  • T Xiao, J Takagi, J-h Wang, BS Coller, TA Springer
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