Integrin inactivators: balancing cellular functions in vitro and in vivo

  title={Integrin inactivators: balancing cellular functions in vitro and in vivo},
  author={Daniel Bouvard and Jeroen Pouwels and Nicola De Franceschi and Johanna Ivaska},
  journal={Nature Reviews Molecular Cell Biology},
Integrins mediate cell–matrix and cell–cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated by their activity switching such that intracellular proteins interacting with the integrin cytoplasmic domains increase or decrease integrin–ligand binding affinity. It is widely accepted that integrin activation by specific proteins is essential for cell adhesion and integrin linkage to the actin… CONTINUE READING
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